escalation: A Modular Approach to Dose-Finding Clinical Trials
Methods for working with dose-finding clinical trials. We provide
implementations of many dose-finding clinical trial designs, including the
continual reassessment method (CRM) by O'Quigley et al. (1990)
<doi:10.2307/2531628>, the toxicity probability interval (TPI) design by Ji
et al. (2007) <doi:10.1177/1740774507079442>, the modified TPI (mTPI) design
by Ji et al. (2010) <doi:10.1177/1740774510382799>, the Bayesian optimal
interval design (BOIN) by Liu & Yuan (2015) <doi:10.1111/rssc.12089>, EffTox
by Thall & Cook (2004) <doi:10.1111/j.0006-341X.2004.00218.x>; the design of
Wages & Tait (2015) <doi:10.1080/10543406.2014.920873>, and the 3+3
described by Korn et al. (1994) <doi:10.1002/sim.4780131802>. All designs
are implemented with a common interface. We also offer optional additional
classes to tailor the behaviour of all designs, including avoiding skipping
doses, stopping after n patients have been treated at the recommended dose,
stopping when a toxicity condition is met, or demanding that n patients are
treated before stopping is allowed. By daisy-chaining together these classes
using the pipe operator from 'magrittr', it is simple to tailor the
behaviour of a dose-finding design so it behaves how the trialist wants.
Having provided a flexible interface for specifying designs, we then provide
functions to run simulations and calculate dose-paths for future cohorts of
patients.
| Version: |
0.2.3 |
| Depends: |
magrittr |
| Imports: |
dplyr, tidyr (≥ 1.0), tidyselect, stringr, purrr, tibble, ggplot2, gtools, dfcrm, BOIN, trialr (≥ 0.1.5), DiagrammeR, RColorBrewer, viridis, binom, R6, mvtnorm, graphics, Iso, testthat |
| Suggests: |
knitr, rmarkdown, covr |
| Published: |
2025-10-08 |
| DOI: |
10.32614/CRAN.package.escalation |
| Author: |
Kristian Brock 
[aut, cre],
Daniel Slade
[aut],
Michael Sweeting
[aut],
Conor Norris
[ctb],
Bharat Bhushan
[ctb] |
| Maintainer: |
Kristian Brock <kristian.brock at gmail.com> |
| BugReports: |
https://github.com/brockk/escalation/issues |
| License: |
GPL (≥ 3) |
| URL: |
https://brockk.github.io/escalation/,
https://github.com/brockk/escalation |
| NeedsCompilation: |
no |
| Materials: |
README, NEWS |
| In views: |
ClinicalTrials |
| CRAN checks: |
escalation results |
Documentation:
| Reference manual: |
escalation.html , escalation.pdf
|
| Vignettes: |
Using escalation (source, R code)
CRM - Continual Reassessment Method (source, R code)
NBG - Neuenschwander, Branson & Gsponer (source, R code)
TPI - Toxicity Probability Interval Design (source, R code)
mTPI - Modified Toxicity Probability Interval Design (source, R code)
BOIN - Bayesian Optimal Interval Design (source, R code)
TITE-CRM and TITE-NBG - Time-to-Event Designs (source, R code)
EffTox, Wages & Tait, and BOIN12 - Efficacy & Toxicity Designs (source, R code)
BOIN-COMB - Treatment Combination Designs (source, R code)
Working with dose-paths (source, R code)
Simulating dose-escalation trials (source, R code)
Comparing dose-escalation designs by simulation (source, R code)
|
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